- 专利标题： METHOD FOR IDENTIFYING COMPOUND FOR INHIBITING AN ACTIVITY OF A HISTONE LYSINE DEMETHYLASE
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申请号： US15835420申请日： 2017-12-07
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公开(公告)号： US20180087118A1公开(公告)日： 2018-03-29
- 发明人: Wen-Ching Wang , Hsing-Jien Kung , Chia-Han Chu , Jing-Moon Yang
- 申请人： NATIONAL TSING HUA UNIVERSITY
- 申请人地址： TW Hsinchu City
- 专利权人： NATIONAL TSING HUA UNIVERSITY
- 当前专利权人： NATIONAL TSING HUA UNIVERSITY
- 当前专利权人地址： TW Hsinchu City
- 主分类号： C12Q1/26
- IPC分类号： C12Q1/26 ; C40B30/02 ; G06F19/16
摘要：
A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.
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