A slider window assembly for a vehicle includes a frame portion, at least one fixed window panel that is fixed relative to the frame portion, and a movable window panel that is movable along upper and lower rails of the frame portion between a closed position and an opened position. A gesture sensing device is operable to sense a gesture of a user in the vehicle and to determine if the sensed gesture is indicative of an open window command or a close window command. A drive system is operable to move the movable window between the opened position and the closed position. The drive system moves the movable window panel responsive to the gesture sensing device determining that a sensed gesture is indicative of an open window command or a close window command.