- 专利标题: LIGAND-TARGETED MOLECULES AND METHODS THEREOF
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申请号: US15844232申请日: 2017-12-15
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公开(公告)号: US20180104353A1公开(公告)日: 2018-04-19
- 发明人: Shiladitya SENGUPTA , Sazid HUSSAIN , Dipankar PRAMANIK , Monideepa ROY , Seikh Samad HOSSAIN
- 申请人: INVICTUS ONCOLOGY PVT. LTD.
- 申请人地址: IN Delhi
- 专利权人: INVICTUS ONCOLOGY PVT. LTD.
- 当前专利权人: INVICTUS ONCOLOGY PVT. LTD.
- 当前专利权人地址: IN Delhi
- 优先权: IN18/DEL/2012 20120103
- 主分类号: C07F15/00
- IPC分类号: C07F15/00 ; A61K47/00 ; A61K31/282
摘要:
The present invention relates to ligand-targeted molecules and ligand drug conjugates (LDCs) comprising a ligand connected to a functional group, which is connected to a linker, with in turn is bonded to a drug. The LDCs of the present invention also comprise platinum coordination complex wherein the platinum is connected to the linker through monocarboxylato and O—*Pt coordinate bonds. The present invention also relates to methods for preparing these ligand drug conjugates. The present invention further relates to methods for the treatment of tumours using the ligand drug conjugates of the present invention.
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