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公开(公告)号:US20170014528A1
公开(公告)日:2017-01-19
申请号:US15124058
申请日:2015-03-11
申请人: Shiladitya SENGUPTA , Monideepa ROY , Nimish GUPTA , Seikh HOSSAIN , INVICTUS ONCOLOGY PVT. LTD.
CPC分类号: C07K16/32 , A61K47/6803 , A61K47/6849 , A61K47/6889 , C07K16/2863 , C07K2317/52 , C07K2317/73
摘要: The current invention discloses targeted drug delivery conjugates comprising a targeting moiety linked to a drug via a molecule having an affinity for the targeting moiety. Typically, the conjugate comprises a targeting ligand and a molecule of interest, e.g., a therapeutic agent. The targeting ligand and the molecule of interest are linked to each other via an affinity ligand. The affinity ligand is further covalently or non-covalently linked to a drug or therapeutic agent. The drug can be modified to make it more soluble and so that it cleaves from the linking molecule at the target site.
摘要翻译: 本发明公开了包含通过对靶向部分具有亲和力的分子与药物连接的靶向部分的靶向药物递送缀合物。 通常,缀合物包含靶向配体和感兴趣的分子,例如治疗剂。 靶向配体和感兴趣的分子通过亲和配体彼此连接。 亲和配体进一步与药物或治疗剂共价或非共价连接。 可以改变药物使其更易溶解,使其在靶位点从连接分子切割。
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公开(公告)号:US20180104353A1
公开(公告)日:2018-04-19
申请号:US15844232
申请日:2017-12-15
IPC分类号: C07F15/00 , A61K47/00 , A61K31/282
CPC分类号: A61K47/60 , A61K31/282 , A61K47/00 , A61K47/50 , A61K47/58 , A61K47/64 , A61K47/641 , A61K47/68 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07F15/0086
摘要: The present invention relates to ligand-targeted molecules and ligand drug conjugates (LDCs) comprising a ligand connected to a functional group, which is connected to a linker, with in turn is bonded to a drug. The LDCs of the present invention also comprise platinum coordination complex wherein the platinum is connected to the linker through monocarboxylato and O—*Pt coordinate bonds. The present invention also relates to methods for preparing these ligand drug conjugates. The present invention further relates to methods for the treatment of tumours using the ligand drug conjugates of the present invention.
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