Invention Application
- Patent Title: TRICYCLIC SULFONES AS ROR GAMMA MODULATORS
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Application No.: US15806554Application Date: 2017-11-08
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Publication No.: US20180127368A1Publication Date: 2018-05-10
- Inventor: David Marcoux , Myra Beaudoin Bertrand , T.G. Murali Dhar , Michael G. Yang , Zili Xiao , Hai-Yun Xiao , Yeheng Zhu , Carolyn A. Weigelt , Douglas G Batt
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Main IPC: C07D211/48
- IPC: C07D211/48 ; C07D213/40 ; C07D295/195 ; C07D213/75 ; C07D333/48 ; C07C317/44 ; C07D335/02 ; C07D471/04 ; C07D307/22 ; C07D241/08 ; C07D207/10 ; C07D207/16 ; C07D231/08 ; C07D309/10 ; C07D211/96 ; C07D471/10 ; C07D205/04 ; C07D207/277 ; C07D257/04 ; C07D205/08 ; A61P37/00

Abstract:
There are described RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US10435369B2 Tricyclic sulfones as ROR gamma modulators Public/Granted day:2019-10-08
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