发明申请
- 专利标题: ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS
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申请号: US15565846申请日: 2016-04-14
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公开(公告)号: US20180134654A1公开(公告)日: 2018-05-17
- 发明人: Tadashi Honda , Wei Li , Suqing Zheng , Albena Dinkova-Kostova
- 申请人: Tadashi Honda , Wei Li , Suqing Zheng , Albena Dinkova-Kostova
- 申请人地址: US NY Albany GB Dundee
- 专利权人: The Research Foundation for the State University of New York,University of Dundee
- 当前专利权人: The Research Foundation for the State University of New York,University of Dundee
- 当前专利权人地址: US NY Albany GB Dundee
- 国际申请: PCT/US16/27514 WO 20160414
- 主分类号: C07C255/46
- IPC分类号: C07C255/46 ; C07C255/47 ; A61K31/277 ; A61P25/28 ; A61P29/00 ; A61P35/00
摘要:
The present invention provides a compound having the structure: wherein X is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, cyano, aryl, heteroaryl, alkylaryl, alkylheteroaryl, alkenylaryl, alkenylheteroaryl, alkynylaryl, alkynylheteroaryl, alkoxy, alkenyloxy, alkynyloxy, aryloxy, heteroaryloxy, acyl, alkylhydroxy, alkylamino, alkenylamino, alkynylamino, amido, carboxyl, or carboxyl ester, or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with Y, Y is H or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with X, or forms an unsubstituted or substituted monocycle with Z; and Z is H or forms an unsubstituted or substituted monocycle with Y; wherein when X and Y are both H, then X is C2alkenyl or C2 alkynyl, and when Y is H forms a substituted cyclohexyl, cycloheptyl with X, the cyclohexyl is other than a trisubstituted cyclohexyl bearing CH3, i-Pr and (CH2)2CO2CH3 groups or CH3, i-Pr and (CH2)3NH2, or a salt or ester thereof.
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