公开(公告)号：US20240327334A1

公开(公告)日：2024-10-03

申请号：US18390287

申请日：2023-12-20

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Xuri GAO ,  Bin WANG ,  Hui CAO ,  Jiajun ZHANG ,  Yuk Ming SIU ,  Jiang LONG ,  Wei LI ,  Matthew C. RHODES ,  Xuechao XING ,  Jianming YU ,  Scott MITCHELL ,  Yat Sun OR

IPC: C07C233/56 ,  A61K31/166 ,  A61K31/277 ,  A61K31/337 ,  A61K31/365 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/662 ,  A61P31/14 ,  C07C243/30 ,  C07C255/46 ,  C07C255/66 ,  C07D205/04 ,  C07D207/16 ,  C07D209/52 ,  C07D209/56 ,  C07D213/40 ,  C07D215/12 ,  C07D231/08 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D249/06 ,  C07D263/32 ,  C07D263/34 ,  C07D265/02 ,  C07D277/28 ,  C07D295/185 ,  C07D305/08 ,  C07D307/58 ,  C07D333/20 ,  C07D333/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07F9/40

CPC classification number: C07C233/56 ,  A61K31/166 ,  A61K31/277 ,  A61K31/337 ,  A61K31/365 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/662 ,  A61P31/14 ,  C07C243/30 ,  C07C255/46 ,  C07C255/66 ,  C07D205/04 ,  C07D207/16 ,  C07D209/52 ,  C07D209/56 ,  C07D213/40 ,  C07D215/12 ,  C07D231/08 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D249/06 ,  C07D263/32 ,  C07D263/34 ,  C07D265/02 ,  C07D277/28 ,  C07D295/185 ,  C07D305/08 ,  C07D307/58 ,  C07D333/20 ,  C07D333/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07F9/4015

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof:




which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240253023A1

公开(公告)日：2024-08-01

申请号：US11867898

申请日：2007-10-05

Applicant: Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

Inventor： Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

IPC: B01J31/02 ,  B01J31/04 ,  B01J31/06 ,  B01J31/12 ,  B01J31/18 ,  B01J31/22 ,  C07B37/02 ,  C07B37/12 ,  C07C45/46 ,  C07C45/69 ,  C07C67/00 ,  C07C255/10 ,  C07C255/17 ,  C07C255/27 ,  C07C255/46 ,  C07C255/65 ,  C07C257/14 ,  C07C311/03 ,  C07C311/04 ,  C07C311/09 ,  C07C311/48 ,  C07C317/04 ,  C07C317/08 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/34 ,  C07C317/44 ,  C07D207/452 ,  C07D213/76 ,  C07D219/10 ,  C07D231/18 ,  C07D233/90 ,  C07D239/60 ,  C07D241/42 ,  C07D249/04 ,  C07D249/10 ,  C07D249/12 ,  C07D251/70 ,  C07D277/64 ,  C07D277/82 ,  C07D285/125 ,  C07D285/135 ,  C07D285/15 ,  C07D285/16 ,  C07D303/34 ,  C07D307/54 ,  C07D307/64 ,  C07D311/52 ,  C07D311/58 ,  C07D311/82 ,  C07D319/06 ,  C07D333/16 ,  C07D333/24 ,  C07D405/06 ,  C07D409/12 ,  C07D417/10 ,  C07D417/14 ,  C07F17/02 ,  C08F4/04 ,  C08G65/334 ,  C09B69/00 ,  C09B69/02 ,  C09B69/10 ,  H01B1/12 ,  H01G9/022 ,  H01G11/02 ,  H01G11/62 ,  H01M4/00 ,  H01M4/38 ,  H01M4/58 ,  H01M4/62 ,  H01M6/00 ,  H01M6/16 ,  H01M6/18 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M10/0568 ,  G02F1/1516 ,  G02F1/1523 ,  H01M4/02 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/40 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/60 ,  H01M4/66 ,  H01M6/04

CPC classification number: B01J31/0224 ,  B01J31/0215 ,  B01J31/0222 ,  B01J31/0225 ,  B01J31/0227 ,  B01J31/0235 ,  B01J31/0239 ,  B01J31/0247 ,  B01J31/0251 ,  B01J31/0252 ,  B01J31/0267 ,  B01J31/0271 ,  B01J31/0281 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/04 ,  B01J31/06 ,  B01J31/068 ,  B01J31/124 ,  B01J31/1815 ,  B01J31/2208 ,  C07B37/02 ,  C07B37/12 ,  C07C45/46 ,  C07C45/69 ,  C07C67/00 ,  C07C255/10 ,  C07C255/17 ,  C07C255/27 ,  C07C255/46 ,  C07C255/65 ,  C07C257/14 ,  C07C311/03 ,  C07C311/04 ,  C07C311/09 ,  C07C311/48 ,  C07C317/04 ,  C07C317/08 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/34 ,  C07C317/44 ,  C07D207/452 ,  C07D213/76 ,  C07D219/10 ,  C07D231/18 ,  C07D233/90 ,  C07D239/60 ,  C07D241/42 ,  C07D249/04 ,  C07D249/10 ,  C07D249/12 ,  C07D251/70 ,  C07D277/64 ,  C07D277/82 ,  C07D285/125 ,  C07D285/135 ,  C07D285/15 ,  C07D285/16 ,  C07D303/34 ,  C07D307/54 ,  C07D307/64 ,  C07D311/52 ,  C07D311/58 ,  C07D311/82 ,  C07D319/06 ,  C07D333/16 ,  C07D333/24 ,  C07D405/06 ,  C07D409/12 ,  C07D417/10 ,  C07D417/14 ,  C07F17/02 ,  C08F4/04 ,  C08G65/3344 ,  C09B69/00 ,  C09B69/02 ,  C09B69/10 ,  H01B1/122 ,  H01B1/128 ,  H01G9/022 ,  H01G11/02 ,  H01G11/62 ,  H01M4/00 ,  H01M4/382 ,  H01M4/5815 ,  H01M4/625 ,  H01M6/00 ,  H01M6/166 ,  H01M6/181 ,  H01M6/183 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M10/0568 ,  B01J2231/122 ,  B01J2231/14 ,  B01J2231/326 ,  B01J2231/341 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/543 ,  B01J2531/35 ,  B01J2531/824 ,  C07C2601/10 ,  C07C2602/42 ,  G02F2001/1518 ,  G02F1/1525 ,  H01M4/02 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/405 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/5825 ,  H01M4/60 ,  H01M4/661 ,  H01M6/04 ,  H01M6/164 ,  H01M6/168 ,  Y02E60/13 ,  Y10S430/127 ,  Y10T29/49108 ,  Y10T428/2918

Abstract: The invention concerns ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic portion M+m in sufficient numbers to ensure overall electronic neutrality; the compound is further comprised of M as a hydroxonium, a nitrosonium NO+, an ammonium —NH4+, a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. The anionic portion matches the formula RF—SOx—N−Z, where RF is a perflourinated group, x is 1 or 3, and Z is an electroattractive substituent. The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorants and the catalysis of various chemical reactions.

公开(公告)号：US20240164138A1

公开(公告)日：2024-05-16

申请号：US18401078

申请日：2023-12-29

Applicant: DONGJIN SEMICHEM CO., LTD. ,  SAMSUNG DISPLAY CO., LTD.

Inventor： Ho Wan HAM ,  Hyun Cheol AN ,  Hee Joo KIM ,  Dong Jun KIM ,  Ja Eun ANN ,  Dong Yuel KWON ,  Sung Kyu LEE ,  Tae Jin LEE ,  Bo Ra LEE ,  Yeong Rong PARK ,  Il Soo OH ,  Dae Woong LEE ,  Hyeon Jeong IM ,  Ill Hun CHO

IPC: H10K50/858 ,  C07C233/58 ,  C07C233/60 ,  C07C255/46 ,  C07C323/40 ,  C07D209/08 ,  C07D211/98 ,  C07D295/32 ,  C07F7/08

CPC classification number: H10K50/858 ,  C07C233/58 ,  C07C233/60 ,  C07C255/46 ,  C07C323/40 ,  C07D209/08 ,  C07D211/98 ,  C07D295/32 ,  C07F7/081 ,  C07C2601/14 ,  C07C2602/28 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2603/68 ,  C07C2603/78

Abstract: A novel compound for a capping layer, and an organic light-emitting device containing the same are disclosed.

公开(公告)号：US11945808B2

公开(公告)日：2024-04-02

申请号：US17841570

申请日：2022-06-15

Applicant: Dart NeuroScience, LLC

Inventor： Jillian Basinger Thompson ,  Brett C. Bookser ,  Scott Burley ,  Pablo Garcia-Reynaga ,  Andrew Hudson ,  Marco Peters ,  Benjamin Pratt ,  Aaron Thompson ,  Joe Tran ,  Lino Valdez

IPC: C07D309/14 ,  A61P25/28 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D207/14 ,  C07D207/273 ,  C07D211/58 ,  C07D211/76 ,  C07D211/96 ,  C07D213/38 ,  C07D401/12 ,  C07D405/12

CPC classification number: C07D405/12 ,  A61P25/28 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D207/14 ,  C07D207/273 ,  C07D211/58 ,  C07D211/76 ,  C07D211/96 ,  C07D213/38 ,  C07D309/14 ,  C07D401/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16

Abstract: Substituted cyclohexyl chemical entities of Formula (I):






wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

公开(公告)号：US20230257341A1

公开(公告)日：2023-08-17

申请号：US18033114

申请日：2021-10-14

Applicant: HEBEI LANSHENG BIOTECH CO., LTD ,  HEBEI LANRUN PLANT PROTECTION TECHNOLOGY CO., LTD ,  HEBEI GUZHIRUN TECHNOLOGY CO., LTD

Inventor： Qingchun GUO ,  Zhengang ZHU ,  Hongyong GUO ,  Xin ZHANG ,  Weiwei LIU

IPC: C07C255/46 ,  C07C253/30 ,  C07C253/34

CPC classification number: C07C255/46 ,  C07C253/30 ,  C07C253/34 ,  C07B2200/13

Abstract: The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C1-10 alkyl or C1-10alkyloxy, C2-10 alkenyl or C2-10 alkenyloxy, C2-10 alkynyl or C2-10 alkynyloxy, C3-10 cycloalkyl or C3-10 cycloalkyloxy, C3-10 heterocycloalkyl or C3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

公开(公告)号：US11433053B2

公开(公告)日：2022-09-06

申请号：US16479602

申请日：2018-01-24

Applicant: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.

Inventor： Lingyun Wu ,  Li Zhang ,  Lele Zhao ,  Jianjun Sun ,  Zhaoguo Chen ,  Jian Li ,  Shuhui Chen

IPC: C07D207/09 ,  C07D207/335 ,  C07D209/44 ,  C07D211/18 ,  C07D211/34 ,  C07D213/38 ,  C07D217/26 ,  C07D223/16 ,  C07D231/12 ,  C07D233/64 ,  C07D249/06 ,  A61K31/4245 ,  A61P35/00 ,  A61K33/243 ,  A61K31/135 ,  A61K31/165 ,  A61K31/277 ,  A61K31/40 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/415 ,  A61K31/417 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/519 ,  A61K31/55 ,  C07C211/40 ,  C07C233/58 ,  C07C255/46 ,  C07D249/08 ,  C07D257/04 ,  C07D261/20 ,  C07D263/56 ,  C07D271/06 ,  C07D277/28 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: A cyclopropylamine compound as a lysine-specific demethylase 1 (LSD1) inhibitor. Particularly, the present invention relates to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. The present invention also provides an application of the same in preparing a drug for treating an LSD1-related disease.

公开(公告)号：US11180461B2

公开(公告)日：2021-11-23

申请号：US16785083

申请日：2020-02-07

Applicant: AUTIFONY THERAPEUTICS LIMITED

Inventor： Agostino Marasco ,  Giuseppe Alvaro ,  Anne Dècor ,  Dieter Hamprecht ,  Paolo Dambruoso ,  Simona Tommasi

IPC: C07D405/14 ,  C07D249/12 ,  C07D307/94 ,  C07D311/04 ,  C07D311/76 ,  C07D311/96 ,  C07D401/04 ,  C07D307/87 ,  C07C43/313 ,  C07C255/46 ,  C07C43/29 ,  C07C255/37 ,  C07C43/225 ,  C07C255/48 ,  C07D405/04

Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.

公开(公告)号：US10273230B2

公开(公告)日：2019-04-30

申请号：US15328450

申请日：2015-07-23

Applicant: Piramal Enterprises Limited

Inventor： Sanjay Kumar ,  Rajiv Sharma ,  Vijaykumar Bhagwan Deore ,  Nilambari Nilkanth Yewalkar

IPC: C07D409/04 ,  C07D405/14 ,  C07D215/14 ,  C07C59/72 ,  C07C255/46 ,  C07C255/54 ,  C07D213/73 ,  C07D309/24 ,  C07D333/16 ,  C07D405/04 ,  C07D277/64 ,  C07D213/30 ,  C07D213/64 ,  C07D307/79 ,  C07C59/66

Abstract: The present invention relates to substituted phenyl alkanoic acid compounds designated as the compound of Formula (I) (as described herein) or a tautomer, a stereoisomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, an N-oxide, a S-oxide or a carboxylic acid isostere thereof; which are GPR120 agonists. The present invention also relates to a pharmaceutical composition of compound of Formula (I) for the treatment of diseases or disorder mediated by GPR120.

公开(公告)号：US20180230398A1

公开(公告)日：2018-08-16

申请号：US15954743

申请日：2018-04-17

Applicant: The Procter & Gamble Company

Inventor： Hugo Robert Germain DENUTTE ,  An PINTENS ,  Johan SMETS ,  Freek Annie Camiel VRIELYNCK ,  Koen VAN AKEN

IPC: C11B9/00 ,  C11D3/50 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/49 ,  C07D493/08 ,  C07D319/08 ,  C07D319/06 ,  C07D309/04 ,  C07D307/36 ,  C07D307/00 ,  C07C255/46 ,  C07C255/07 ,  C07C251/40 ,  C07C233/58 ,  C07C69/75 ,  C07C69/74 ,  C07C69/533 ,  C07C69/145 ,  C07C69/14 ,  C07C69/07 ,  C07C69/013 ,  C07C49/84 ,  C07C49/563 ,  C07C49/543 ,  C07C49/533 ,  C07C49/255 ,  C07C49/21 ,  C07C49/203 ,  C07C49/20 ,  C07C47/575 ,  C07C47/47 ,  C07C47/45 ,  C07C47/42 ,  C07C33/14 ,  C07C33/025 ,  C07C31/125 ,  A61Q13/00 ,  A61Q11/00 ,  A61Q5/02 ,  A61K8/88 ,  A61K8/81

Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

公开(公告)号：US20180134654A1

公开(公告)日：2018-05-17

申请号：US15565846

申请日：2016-04-14

Applicant: Tadashi Honda ,  Wei Li ,  Suqing Zheng ,  Albena Dinkova-Kostova

Inventor： Tadashi Honda ,  Wei Li ,  Suqing Zheng ,  Albena Dinkova-Kostova

IPC: C07C255/46 ,  C07C255/47 ,  A61K31/277 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07C255/46 ,  A61K31/277 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07C255/47 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2602/24 ,  C07C2603/18 ,  C07C2603/26

Abstract: The present invention provides a compound having the structure: wherein X is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, cyano, aryl, heteroaryl, alkylaryl, alkylheteroaryl, alkenylaryl, alkenylheteroaryl, alkynylaryl, alkynylheteroaryl, alkoxy, alkenyloxy, alkynyloxy, aryloxy, heteroaryloxy, acyl, alkylhydroxy, alkylamino, alkenylamino, alkynylamino, amido, carboxyl, or carboxyl ester, or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with Y, Y is H or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with X, or forms an unsubstituted or substituted monocycle with Z; and Z is H or forms an unsubstituted or substituted monocycle with Y; wherein when X and Y are both H, then X is C2alkenyl or C2 alkynyl, and when Y is H forms a substituted cyclohexyl, cycloheptyl with X, the cyclohexyl is other than a trisubstituted cyclohexyl bearing CH3, i-Pr and (CH2)2CO2CH3 groups or CH3, i-Pr and (CH2)3NH2, or a salt or ester thereof.