Systems and methods are provided for generating reference signals with high interference immunity. A signal source may generate reference signals having a particular reference frequency based on characteristics of the source of the reference signals, for use in driving at least one component in a system. One or more processing may then process the generated reference signals, based on particular frequency positions relative to the particular reference frequency and other operations and/or components of the system. The processing may include filtering at the particular frequency positions. The particular frequency positions may correspond to the harmonics positions of the particular reference frequency. The signal source may be a crystal oscillator.