发明申请
- 专利标题： COMBINATION OF A PD-1 ANTAGONIST AND CPG-C TYPE OLIGONUCLEOTIDE FOR TREATING CANCER
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申请号： US15577369申请日： 2016-05-26
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公开(公告)号： US20180169229A1公开(公告)日： 2018-06-21
- 发明人: Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN
- 申请人： Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN , MERCK SHARP & DOHME CORP. , DYNAVAX TECHNOLOGIES CORPORATION
- 申请人地址： US NJ Rahway US CA Berkeley
- 专利权人： MERCK SHARP & DOHME CORP.,DYNAVAX TECHNOLOGIES CORPORATION
- 当前专利权人： MERCK SHARP & DOHME CORP.,DYNAVAX TECHNOLOGIES CORPORATION
- 当前专利权人地址： US NJ Rahway US CA Berkeley
- 国际申请： PCT/US16/34275 WO 20160526
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/7115 ; A61K45/06 ; C07K14/435 ; A61P35/00
摘要：
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
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