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公开(公告)号：US20180169229A1
公开(公告)日：2018-06-21
申请号：US15577369
申请日：2016-05-26
申请人： Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN , MERCK SHARP & DOHME CORP. , DYNAVAX TECHNOLOGIES CORPORATION
发明人： Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN
IPC分类号： A61K39/395 , A61K31/7115 , A61K45/06 , C07K14/435 , A61P35/00
摘要： The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
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2.发明申请公开(公告)号：US20180161427A1
公开(公告)日：2018-06-14
申请号：US15577377
申请日：2016-05-26
申请人： Ying YU , Elliot Keith CHARTASH , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN , MERCK SHARP & DOHME CORP. , DYNAVAX TECHNOLOGIES CORPORATION
发明人： Ying YU , Elliot Keith CHARTASH , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN
IPC分类号： A61K39/395 , A61K31/7125 , A61P35/00
CPC分类号： A61K39/3955 , A61K31/7125 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/55561 , A61P35/00 , C07K16/244
摘要： The present disclosure describes combination therapies comprising an anti-IL-10 antibody or antigen-binding fragment thereof and a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
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公开(公告)号：US20210196819A1
公开(公告)日：2021-07-01
申请号：US17000149
申请日：2020-08-21
发明人： Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN
IPC分类号： A61K39/395 , A61K45/06 , A61K31/7115 , C07K14/435 , A61K39/39 , C07K16/28 , C07K16/24 , A61P35/00
摘要： The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (T1119) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
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公开(公告)号：US20190240323A1
公开(公告)日：2019-08-08
申请号：US15958295
申请日：2018-04-20
IPC分类号： A61K39/39 , A61K47/61 , C07H21/00 , A61K47/60 , A61K39/12 , C07H21/04 , A61K31/7125 , A61K39/07
CPC分类号： A61K39/39 , A61K31/7125 , A61K39/07 , A61K39/12 , A61K47/60 , A61K47/61 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , C07H21/00 , C07H21/04 , C12N2730/10134
摘要： The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
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5.发明申请公开(公告)号：US20190151462A1
公开(公告)日：2019-05-23
申请号：US16190010
申请日：2018-11-13
IPC分类号： A61K47/65 , A61K47/68 , A61P35/00 , A61K47/60 , A61K31/4745
摘要： The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.
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6.发明申请公开(公告)号：US20160346312A1
公开(公告)日：2016-12-01
申请号：US15162535
申请日：2016-05-23
IPC分类号： A61K31/713 , A61K9/00 , A61K45/06
CPC分类号： A61K31/713 , A61K9/0073 , A61K31/7125 , A61K45/06
摘要： The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.
摘要翻译： 本公开涉及通过肺内施用多核苷酸Toll样受体9激动剂治疗癌症的方法。 本公开的方法适用于治疗肺的原发性癌症，以及肺转移性癌症及其额外的肺癌。 另外，本公开提供具有适于肺内给药的免疫刺激和毒性特征的多核苷酸Toll样受体9激动剂。
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公开(公告)号：US20240182478A1
公开(公告)日：2024-06-06
申请号：US18484588
申请日：2023-10-11
IPC分类号： C07D487/04 , A61K45/06 , C07D231/56 , C07D235/18 , C07D519/00
CPC分类号： C07D487/04 , A61K45/06 , C07D231/56 , C07D235/18 , C07D519/00
摘要： The invention relates to compounds of formula (I):
or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.-
8.发明申请公开(公告)号：US20180360954A1
公开(公告)日：2018-12-20
申请号：US15958292
申请日：2018-04-20
IPC分类号： A61K39/39 , A61K31/7125
CPC分类号： A61K39/39 , A61K31/7125 , A61K39/07 , A61K39/12 , A61K47/60 , A61K47/61 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , C07H21/00 , C07H21/04 , C12N2730/10134
摘要： The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
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公开(公告)号：US20160003807A1
公开(公告)日：2016-01-07
申请号：US14694919
申请日：2015-04-23
IPC分类号： G01N33/50 , C07K14/705 , C12N5/0789
CPC分类号： G01N33/5073 , A01K67/0271 , A01K67/0278 , A01K2217/052 , A01K2227/105 , A01K2267/0387 , C07K14/705 , C07K14/70596 , C12N5/0647 , C12N2510/00 , G01N33/502 , G01N33/5023 , G01N33/5038
摘要： Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.
摘要翻译： 本文提供了表达转基因动物的人Toll样受体8（TLR8）及其使用方法。
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10.发明申请公开(公告)号：US20180264023A1
公开(公告)日：2018-09-20
申请号：US15989055
申请日：2018-05-24
IPC分类号： A61K31/713 , A61K31/7125 , A61K9/00 , A61K45/06
CPC分类号： A61K31/713 , A61K9/0073 , A61K31/7125 , A61K45/06
摘要： The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.
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