- 专利标题： CARBONIC ANHYDRASE IX-SPECIFIC ANTIBODIES AND USES THEREOF
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申请号： US15580713申请日： 2016-06-10
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公开(公告)号： US20180186893A1公开(公告)日： 2018-07-05
- 发明人: Anne E.G. Lenferink , Maureen D. O'Connor , Anne Marcil , Yves Durocher
- 申请人： National Research Council of Canada
- 申请人地址： CA ON Ottawa
- 专利权人： National Research Council of Canada
- 当前专利权人： National Research Council of Canada
- 当前专利权人地址： CA ON Ottawa
- 国际申请： PCT/IB2016/053448 WO 20160610
- 主分类号： C07K16/40
- IPC分类号： C07K16/40 ; A61K47/68 ; G01N33/573 ; A61K51/10
摘要：
The present invention relates to isolated or purified antibodies or fragments thereof specific for Carbohydrate Anhydrase IX (CA-IX) and their use as therapeutic tools. Specifically, the present invention is directed to high-affinity Carbohydrate Anhydrase IX-specific antibodies and fragments thereof and their use as antibody-drug conjugates. Compositions for use in therapy as well as therapeutic methods are also described.
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