A multicolored silicone synthetic leather includes an A colored silica layer, a B colored silica layer and a substrate sequentially disposed from top to bottom. Colors of the A colored silica layer and the B colored silica layer are different. A preparing method adopts silicone slurries with two colors, respectively are a slurry A and a slurry B; the slurry A is coated on release paper for vulcanization, and a thickness for coating is 0.01-0.1 mm; the slurry B is coated on the vulcanizated slurry A, and times for coating is more than one, and except final coating, the vulcanization is requested for the silicone slurries before next coating in former coating processes; the final coating is attached to a substrate for the vulcanization; the multicolored silicone synthetic leather is obtained after peeling the release paper. The synthetic leather prepared in the disclosure is environmentally friendly and harmless to human.