- 专利标题： COMPOUNDS AND METHODS FOR DETECTION OF ENZYMES THAT REMOVE FORMYL, SUCCINYL, METHYL SUCCINYL OR MYRISTOYL GROUPS FROM EPSILON-AMINO LYSINE MOIETIES
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申请号： US15944336申请日： 2018-04-03
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公开(公告)号： US20180223328A1公开(公告)日： 2018-08-09
- 发明人: Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
- 申请人： Enzo Life Sciences, Inc.
- 申请人地址： US NY Farmingdale
- 专利权人： Enzo Life Sciences, Inc.
- 当前专利权人： Enzo Life Sciences, Inc.
- 当前专利权人地址： US NY Farmingdale
- 主分类号： C12Q1/34
- IPC分类号： C12Q1/34 ; C07D493/10 ; C07D311/16
摘要：
Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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