A deactivation method and system in a crosstalk scenario which relates to the field of mobile communications technologies. The method includes M transceivers of a central office end sending data using M lines, and when the M transceivers are in a data transmission showtime state, and when a trigger state change event is detected, switching, by N transceivers, to a deactivation execution state, to deactivate N lines among the M lines, acquiring an update coefficient used to update a crosstalk cancellation coefficient between active lines, updating the crosstalk cancellation coefficient between the active lines using the update coefficient, and controlling the transceivers in the deactivation execution state to enter a silent or an idle state.