A method for multiple frame transmission in a wireless communication system and a transmitter are provided. The transmitter transmits a request to send (RTS) frame to a receiver. The RTS frame has a first bandwidth. The transmitter receives a clear to send (CTS) frame as a response of the RTS frame from the receiver to establish a transmission opportunity (TXOP) indicating an interval of time when the transmitter has the right to transmit at least one data frame. The CTS frame has a second bandwidth. The transmitter transmits a plurality of data frames sequentially to the receiver during the TXOP.