发明申请
- 专利标题: NEPRILYSIN INHIBITORS
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申请号: US15841749申请日: 2017-12-14
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公开(公告)号: US20180237423A1公开(公告)日: 2018-08-23
- 发明人: Melissa Fleury , Adam D. Hughes
- 申请人: THERAVANCE BIOPHARMA R&D IP, LLC
- 申请人地址: US CA South San Francisco
- 专利权人: THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人: THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人地址: US CA South San Francisco
- 主分类号: C07D405/12
- IPC分类号: C07D405/12 ; A61K31/4192 ; C07D231/20 ; C07D231/14 ; C07D249/04 ; C07D261/18 ; C07D263/38 ; A61K31/415 ; A61K31/42 ; A61K31/421 ; A61K45/06
摘要:
In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
公开/授权文献
- US10189823B2 Neprilysin inhibitors 公开/授权日:2019-01-29
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