Invention Application
- Patent Title: CROSSLINKED NUCLEIC ACID GUNA, METHOD FOR PRODUCING SAME, AND INTERMEDIATE COMPOUND
-
Application No.: US15760513Application Date: 2016-09-20
-
Publication No.: US20180251488A1Publication Date: 2018-09-06
- Inventor: Satoshi OBIKA , Eiji KAWANISHI , Hiroaki SAWAMOTO , Shuhei YAMAKOSHI , Yuuki ARAI , Shinji KUMAGAI
- Applicant: MITSUBISHI TANABE PHARMA CORPORATION , OSAKA UNIVERSITY
- Applicant Address: JP Osaka-shi, Osaka JP Suita-shi, Osaka
- Assignee: MITSUBISHI TANABE PHARMA CORPORATION,OSAKA UNIVERSITY
- Current Assignee: MITSUBISHI TANABE PHARMA CORPORATION,OSAKA UNIVERSITY
- Current Assignee Address: JP Osaka-shi, Osaka JP Suita-shi, Osaka
- Priority: JP2015-185730 20150918; JP2016-039351 20160301
- International Application: PCT/JP2016/077748 WO 20160920
- Main IPC: C07H19/06
- IPC: C07H19/06 ; C07H9/06
Abstract:
The present invention provides a method for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate compound for the production thereof. Specifically, the present invention provides a method for producing a compound represented by general formula I: (in the formula, R1, R2, R3, R4, R5, R6, m and ring A are as defined in the specification) or a salt thereof wherein a reducing agent is reacted with a compound represented by general formula II: (in the formula, R1, R2, R3, R4, R5, R6, m, and ring A′ are as defined in the specification).
Public/Granted literature
- US10961269B2 Bridged nucleic acid GuNA, method for producing same, and intermediate compound Public/Granted day:2021-03-30
Information query
IPC分类:
