专利检索 ap:("MITSUBISHI TANABE PHARMA CORPORATION" OR "OSAKA UNIVERSITY") AND inv:"Yuuki ARAI" 第 1 页

1.

发明申请
CROSSLINKED NUCLEIC ACID GUNA, METHOD FOR PRODUCING SAME, AND INTERMEDIATE COMPOUND 审中-公开

公开(公告)号：US20180251488A1

公开(公告)日：2018-09-06

申请号：US15760513

申请日：2016-09-20

申请人： MITSUBISHI TANABE PHARMA CORPORATION , OSAKA UNIVERSITY

发明人： Satoshi OBIKA , Eiji KAWANISHI , Hiroaki SAWAMOTO , Shuhei YAMAKOSHI , Yuuki ARAI , Shinji KUMAGAI

IPC分类号： C07H19/06 , C07H9/06

CPC分类号： C07H19/06 , C07C279/16 , C07D498/04 , C07D498/08 , C07H1/00 , C07H9/06 , C07H19/16 , C07H21/00

摘要： The present invention provides a method for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate compound for the production thereof. Specifically, the present invention provides a method for producing a compound represented by general formula I: (in the formula, R1, R2, R3, R4, R5, R6, m and ring A are as defined in the specification) or a salt thereof wherein a reducing agent is reacted with a compound represented by general formula II: (in the formula, R1, R2, R3, R4, R5, R6, m, and ring A′ are as defined in the specification).