- 专利标题： PDGF and VEGF Aptamers Having Improved Stability and Their Use in Treating PDGF and VEGF Mediated Diseases and Disorders
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申请号： US15975962申请日： 2018-05-10
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公开(公告)号： US20180258432A1公开(公告)日： 2018-09-13
- 发明人: Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
- 申请人： SomaLogic, Inc.
- 主分类号： C12N15/115
- IPC分类号： C12N15/115
摘要：
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
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