-
1.发明申请PDGF and VEGF Aptamers Having Improved Stability and Their Use in Treating PDGF and VEGF Mediated Diseases and Disorders 有权具有改善的稳定性的PDGF和VEGF调节剂及其在治疗PDGF和VEGF介导的疾病和障碍中的用途公开(公告)号：US20160177307A1
公开(公告)日：2016-06-23
申请号：US14909305
申请日：2014-09-08
申请人： SomaLogic, Inc.
发明人： Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/344 , C12N2310/346 , C12N2320/51 , C12N2310/3521
摘要： Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
摘要翻译： 提供了对结合PDGF的核酸酶和结合VEGF的适体具有改善的稳定性的适配子。 此外，提供了包含PDGF适体和VEGF适体的适体构建体。 提供了包含适体和适体构建体的药物组合物，以及使用适体和适体构建体治疗病症的方法。
-
2.发明申请公开(公告)号：US20180258432A1
公开(公告)日：2018-09-13
申请号：US15975962
申请日：2018-05-10
申请人： SomaLogic, Inc.
发明人： Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/344 , C12N2310/346 , C12N2320/51 , C12N2310/3521
摘要： Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
-
公开(公告)号：US20170247702A1
公开(公告)日：2017-08-31
申请号：US15594921
申请日：2017-05-15
申请人： SomaLogic, Inc.
发明人： Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/344 , C12N2310/346 , C12N2320/51 , C12N2310/3521
摘要： Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
-
公开(公告)号：US09695424B2
公开(公告)日：2017-07-04
申请号：US14909305
申请日：2014-09-08
申请人： SomaLogic, Inc.
发明人： Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/344 , C12N2310/346 , C12N2320/51 , C12N2310/3521
摘要： Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
-
公开(公告)号：US10544419B2
公开(公告)日：2020-01-28
申请号：US15975962
申请日：2018-05-10
申请人： SomaLogic, Inc.
发明人： Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
IPC分类号： C12N15/115
摘要： Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
-
公开(公告)号：US09994857B2
公开(公告)日：2018-06-12
申请号：US15594921
申请日：2017-05-15
申请人： SomaLogic, Inc.
发明人： Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/344 , C12N2310/346 , C12N2320/51 , C12N2310/3521
摘要： Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.022 秒)
