发明申请
- 专利标题： Beta-Alanine Aminotransferases For The Production of 3-Hydroxypropionic Acid
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申请号： US15754402申请日： 2016-08-24
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公开(公告)号： US20180265902A1公开(公告)日： 2018-09-20
- 发明人: Monica Tassone , Audrey Diano
- 申请人： Novozymes A/S
- 申请人地址： DK Bagsvaerd
- 专利权人： Novozymes A/S
- 当前专利权人： Novozymes A/S
- 当前专利权人地址： DK Bagsvaerd
- 国际申请： PCT/US2016/048474 WO 20160824
- 主分类号： C12P7/42
- IPC分类号： C12P7/42 ; C12N9/10 ; C07C51/377 ; C07C67/08 ; C07C29/149
摘要：
Provided herein are recombinant host cells having an active 3-Hydroxypropionic Acid (3-HP) pathway wherein the host cells comprise a heterologous polynucleotide encoding an aminotransferase of E.C. 2.6.1.19 and wherein the aminotransferase comprises the motif (A,C)-Xn-(GSLS)-Xn-SKA(L/l)(L/l). Also described are methods of making the host cells, and methods using the cells to produce 3-HP and derivatives of 3-HP (e.g., acrylic acid).
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