Systems and methods are provided for upgrading a mixture of catalytic slurry oil and coker bottoms by hydroprocessing. Optionally, the upgrading can further include deasphalting the mixture of catalytic slurry oil and coker bottoms to form a deasphalted oil and a deasphalter residue or rock fraction. The mixture of catalytic slurry oil and coker bottoms and/or the deasphalted oil can then be hydroprocessed to form an upgraded effluent that includes fuels boiling range products. Optionally, in some aspects where the feed mixture is deasphalted prior to hydroprocessing, the feed mixture can further include a portion of a (sour) vacuum resid.