A method for performing inter-frequency positioning measurements on positioning signals periodically transmitted by at least some of a plurality of cells in a wireless communication network is provided. The method includes receiving, at a mobile device, assistance data that identifies a first neighbor cell the plurality of cells, where the first neighbor cell transmits a first positioning signal. The method also includes obtaining a first cell property of the first neighbor cell. The mobile device then adjusts a duration of a first measurement gap in response to the first cell property. In one aspect, the first measurement gap corresponds to a time period during which the mobile device is to perform positioning measurements of the first positioning signal.