- 专利标题: HETEROARYLCARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS
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申请号: US15770763申请日: 2016-10-20
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公开(公告)号: US20180319771A1公开(公告)日: 2018-11-08
- 发明人: Sara FRATTINI , Remko BAKKER , Riccardo GIOVANNINI , Giacomo FOSSATI , Dieter HAMPRECHT , Iain LINGARD , Alexander PAUTSCH , Bernd WELLENZOHN
- 申请人: Boehringer Ingelheim International GmbH
- 优先权: EP15191759.8 20151027
- 国际申请: PCT/EP2016/075222 WO 20161020
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D471/04 ; C07D487/04 ; C07D405/14 ; C07D491/052 ; C07D498/04 ; C07D498/10 ; A61P3/10
摘要:
The present invention relates to compounds of general formula (I), wherein D1 to D3, -A-, n, R1, R2, Y1, L and y2 are defined as in claim 1, which have valuable pharmacological properties, in particular are inhibitors of plasma kallikrein. The compounds are suitable for treatment and prevention of diseases which can be influenced by inhibition of plasma kallikrein, such as diabetic complications, particularly in the treatment of retinal vascular permeability associated with diabetic retinopathy and diabetic macular edema.