Data compression techniques are provided that remove redundancy across the boundary of compression search engines. An illustrative method comprises splitting the data frame into a plurality of sub-chunks; comparing at least two of the plurality of sub-chunks to one another to remove at least one sub-chunk from the plurality of sub-chunks that substantially matches at least one other sub-chunk to generate a remaining plurality of sub-chunks; generating matching sub-chunk information for data reconstruction identifying the at least one removed sub-chunk and the corresponding substantially matched at least one other sub-chunk; grouping the remaining plurality of sub-chunks into sub-units; removing substantially repeated patterns within the sub-units to generate corresponding compressed sub-units; and combining the compressed sub-units with the matching sub-chunk information to generate a compressed data frame. The data frame optionally comprises one or more host pages compressed substantially simultaneously, and the compressed data frame for a plurality of host pages compressed substantially simultaneously comprises a host page address for each host page.