发明申请
- 专利标题： METHODS AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS
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申请号： US15794788申请日： 2017-10-26
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公开(公告)号： US20180334658A1公开(公告)日： 2018-11-22
- 发明人: Darrel W. Stafford , Tao Li
- 申请人： The University of North Carolina at Chapel Hill
- 主分类号： C12N9/04
- IPC分类号： C12N9/04 ; C12N9/50 ; C12Q1/6883 ; C12N9/88
摘要：
The present invention provides a stable cell line overexpressing a recombinant vitamin K-dependent (VKD) protein and both a recombinant vitamin K epoxide reductase (VKOR) and a recombinant vitamin K dependent gamma carboxylase (VKGC), wherein the amount of fully carboxylated VKD protein produced in the cell is increased 10% as compared to the amount of fully carboxylated VKD protein produced in the cell in the absence of the recombinant VKOR and the recombinant VKGC.
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