- 专利标题: MONONUCLEOTIDES HAVING A BIOREVERSIBLE DISULFIDE GROUP
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申请号: US15534022申请日: 2015-12-10
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公开(公告)号: US20180346505A1公开(公告)日: 2018-12-06
- 发明人: Curt W. BRADSHAW , Sukumar SAKAMURI , Dingguo LIU
- 申请人: SOLSTICE BIOLOGICS, LTD.
- 国际申请: PCT/US15/65026 WO 20151210
- 主分类号: C07H19/10
- IPC分类号: C07H19/10 ; A61P31/14
摘要:
The invention features a mononucleotide comprising a nucleobase bonded to a sugar having a 3′-carbon and a 5′-carbon, where the 5′-carbon is bonded to a phosphorus (V) atom of a phosphate group through an oxygen atom, the phosphorus (V) atom being bonded to (i) a disulfide bioreversible group through an oxygen atom; and (ii) (a) optionally substituted amino, optionally substituted alkoxy, optionally substituted aryloxy, or optionally substituted heteroaryloxy; or (b) the 3′-carbon through an oxygen atom. The invention also features methods of delivering the mononucleotide to a cell and methods of treating a subject having Hepatitis C.