- 专利标题： PRODUCTION OF T CELL RETARGETING HETERO-DIMERIC IMMUNOGLOBULINS
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申请号： US15984822申请日： 2018-05-21
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公开(公告)号： US20180355064A1公开(公告)日： 2018-12-13
- 发明人: Stanislas BLEIN , Romain OLLIER , Darko SKEGRO , Samuel HOU
- 申请人： GLENMARK PHARMACEUTICALS S.A.
- 申请人地址： CH La Chaux-de-Fonds
- 专利权人： GLENMARK PHARMACEUTICALS S.A.
- 当前专利权人： GLENMARK PHARMACEUTICALS S.A.
- 当前专利权人地址： CH La Chaux-de-Fonds
- 优先权： EP13191386.5 20131104
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; C07K16/28 ; C07K16/42 ; C07K16/32
摘要：
The present invention describes novel hetero-dimeric immunoglobulins or fragments thereof which bind to CD3 and a disease associated antigen. These hetero-dimeric immunoglobulins have been engineered to promote hetero-dimer formation during expression and can be purified to a high degree using a Protein A differential purification technique.
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