The invention relates to a cosmetic or dermatological composition containing a polyphenol-enriched extract of Vitex Negundo, typically a root extract obtained using a PAT plant milking®process. The invention further relates to a composition of this kind for use in the prevention or treatment of disorders and diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of extrinsic or intrinsic skin aging. Lastly, the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, said method consisting in administering such a composition or such an extract.