Invention Application
- Patent Title: BRIDGED PIPERIDINE DERIVATIVES
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Application No.: US16004145Application Date: 2018-06-08
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Publication No.: US20190010156A1Publication Date: 2019-01-10
- Inventor: Bjoern BARTELS , Hasane RATNI , Karlheinz BAUMANN , Guido GALLEY , Georg JAESCHKE , Roland JAKOB-ROETNE , Anja LIMBERG , Werner NEIDHART , Rosa Maria RODRIGUEZ-SARMIENTO
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Priority: EP15199260.9 20151210
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D471/04 ; A61P25/28

Abstract:
The present invention relates to a compound of formula wherein HetAr is a five or six membered hetaryl group, containing one, two or three heteroatoms, selected from N, O or S; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, or lower alkoxy; R2 is lower alkyl substituted by halogen, —CH2—C3-6-cycloalkyl, substituted by one or two substituents, selected from lower alkyl substituted by halogen or halogen, or is lower alkenyl substituted by halogen; R3 is hydrogen, lower alkyl substituted by halogen, lower alkyl, halogen, C3-6-cycloalkyl or lower alkyl substituted by hydroxy; n is 1 or 2; for n=2, R1 can be independent to each other; Y is CH or N; or to a pharmaceutically active acid addition salt thereof, to a racemic mixture or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
Public/Granted literature
- US10562903B2 Bridged piperidine derivatives Public/Granted day:2020-02-18
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