Methods for transmitting a waveform in the wireless communication networks are provided. A method for UE to transmit to an eNB an uplink channel carrying data or control information bits, comprising: receiving a downlink channel occupying a set of downlink resource elements, where each downlink resource element has a downlink subcarrier spacing in the frequency domain and a downlink symbol duration in the time domain; generating a SC-FDMA based uplink channel from the information bits, where the uplink channel occupies a set of uplink resource elements and each uplink resource element has a uplink subcarrier spacing in the frequency domain differing from the downlink subcarrier spacing, and a uplink symbol duration in the time domain differing from the downlink symbol duration; and transmitting the SC-FDMA based uplink channel. In one embodiment, the information bits are uplink data information bits. In another embodiment, the information bits are uplink control information bits.