Invention Application
- Patent Title: FUSION POLYPEPTIDE IN WHICH ANTI-INFLAMMATORY POLYPEPTIDE AND FERRITIN MONOMER FRAGMENT ARE BOUND AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT
-
Application No.: US15757580Application Date: 2016-09-02
-
Publication No.: US20190016764A1Publication Date: 2019-01-17
- Inventor: Jong-Sup BAE , In-San KIM , Won Hwa LEE , Jun Young SEO , So Youn KIM
- Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daegu KR Seoul
- Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION,KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION,KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Daegu KR Seoul
- Priority: KR10-2015-0124472 20150902
- International Application: PCT/KR2016/009845 WO 20160902
- Main IPC: C07K14/47
- IPC: C07K14/47 ; C07K14/79 ; C12N15/62 ; A61P29/00 ; C07K14/54 ; A61K47/64

Abstract:
The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases. As in the above, the fusion polypeptide, which has an amino acid sequence represented by SEQ ID NO: 1 and in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a fragment of a human-derived ferritin monomer, can fuse two types of anti-inflammatory polypeptides, acting through different mechanisms, into a nano cage and administer the same, and thus the fusion polypeptide can exhibit an excellent effect in the treatment of inflammatory diseases including sepsis.
Public/Granted literature
Information query