发明申请
- 专利标题： CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
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申请号： US15967510申请日： 2018-04-30
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公开(公告)号： US20190040399A1公开(公告)日： 2019-02-07
- 发明人: Feng ZHANG , Le CONG , David Benjamin Turitz COX , Patrick HSU , Shuailiang LIN , Fei RAN , Randall Jeffrey PLATT , Neville Espi SANJANA
- 申请人： THE BROAD INSTITUTE INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 主分类号： C12N15/74
- IPC分类号： C12N15/74 ; C12N9/22 ; C12N15/113 ; C12N15/63 ; C12N15/70 ; C12N15/85 ; C12N15/90 ; C12N15/10
摘要：
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/CAS system.
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