- 专利标题: Process For Preparing Spirogalbanone
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申请号: US16070687申请日: 2017-02-13
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公开(公告)号: US20190055181A1公开(公告)日: 2019-02-21
- 发明人: Simon ELLWOOD , William Alexander THIAM
- 申请人: Givaudan, S.A.
- 优先权: GB1602644.5 20160215
- 国际申请: PCT/EP2017/053112 WO 20170213
- 主分类号: C07C45/51
- IPC分类号: C07C45/51 ; C07C41/01 ; C07C41/30 ; C07C41/18 ; C07C49/557
摘要:
A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalisation reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.
公开/授权文献
- US10227280B1 Process for preparing spirogalbanone 公开/授权日:2019-03-12
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