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    PROCESS FOR PRODUCING CAROTENOID
    2.
    发明申请
    PROCESS FOR PRODUCING CAROTENOID 有权
    生产CAROTENOID的方法

    公开(公告)号：US20120004319A1

    公开(公告)日：2012-01-05

    申请号：US13203324

    申请日：2010-03-01

    申请人： Kentaro Shimizu ,  Tomoyuki Ishizaki ,  Toshiyuki Takahashi ,  Shotaro Uchizawa

    发明人： Kentaro Shimizu ,  Tomoyuki Ishizaki ,  Toshiyuki Takahashi ,  Shotaro Uchizawa

    IPC分类号： A61K31/122 ,  C07C49/573 ,  A61K8/35 ,  A61P43/00 ,  A61Q90/00 ,  C12P7/26 ,  C07C49/557

    CPC分类号： C12R1/01 ,  A23L5/44 ,  A23L33/105 ,  A61K31/122 ,  C12P23/00

    摘要： The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.

    摘要翻译： 本发明提供一种含有类胡萝卜素的组合物的制造方法，包括以下步骤：使用水溶性有机溶剂对产生类胡萝卜素的微生物的培养物进行萃取处理; 将得到的提取液分散在水中进行胶束化; 在溶剂中加热搅拌得到的胶束化溶液使胶束破裂并沉淀出目的类胡萝卜素成分，得到沉淀物; 用乙醇收集和洗涤沉淀物; 并进一步对沉淀物进行粉碎/干燥; 食品，药物组合物和含有类胡萝卜素的组合物的化妆品。

    Liver protection compounds of the cyclohexenone type from Antrodia camphorata
    3.
    发明授权
    Liver protection compounds of the cyclohexenone type from Antrodia camphorata 失效
    来自樟芝的环己烯酮类型的肝保护化合物

    公开(公告)号：US07456225B1

    公开(公告)日：2008-11-25

    申请号：US11902599

    申请日：2007-09-24

    申请人： Sheng-Yun Liu ,  Wu-Che Wen ,  Mao-Tien Kuo

    发明人： Sheng-Yun Liu ,  Wu-Che Wen ,  Mao-Tien Kuo

    IPC分类号： A61K31/12 ,  C07C49/543 ,  C07C49/557

    CPC分类号： A61K36/07 ,  A61K31/12 ,  C07C403/02 ,  C07C2601/16

    摘要： The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.

    摘要翻译： 本发明涉及一种用于肝保护的樟脑类化合物，特别涉及一种提取物，4-羟基-2,3-二甲氧基-6-甲基-5（3,7,11-三甲基 - 十二烷-2,6- ，10-三烯基） - 环己-2-烯酮，其从樟脑中分离。 根据本发明的环己烯酮化合物有助于缓解由化学物质引起的肝脏损伤和纤维化，并降低丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的水平。 通过增加谷胱甘肽过氧化物酶（GSHPx）和过氧化氢酶（CAT）的含量，环己烯酮进一步降低了肝脏损伤和自由基引起的氧化压力，提高了抗氧化能力，达到了肝脏保护的目的。

    Cycloaliphatic ketones for use as perfuming and flavoring ingredients
    5.
    发明授权
    Cycloaliphatic ketones for use as perfuming and flavoring ingredients 失效
    用作加香和调味成分的环脂肪酮

    公开(公告)号：US5041678A

    公开(公告)日：1991-08-20

    申请号：US590200

    申请日：1990-09-28

    申请人： Charles Fehr ,  Jose Galindo

    发明人： Charles Fehr ,  Jose Galindo

    IPC分类号： A23L2/00 ,  A23L29/00 ,  A24B15/28 ,  A61K8/35 ,  A61Q13/00 ,  C07B31/00 ,  C07B53/00 ,  C07C45/00 ,  C07C45/42 ,  C07C45/67 ,  C07C49/21 ,  C07C49/557 ,  C07C67/00 ,  C07C403/00 ,  C11B9/00

    CPC分类号： C07C403/08 ,  C07C403/16 ,  C11B9/0034 ,  C07B2200/07 ,  C07C2101/16

    摘要： Optically active isomers of alpha-damascone of formula ##STR1## wherein the wavy line designates a C--C bound of cis or trans configuration and its 3-buten-1-one derivative are new compounds having utility in the perfume and flavor industry. They can be prepared starting from an enolate of formula ##STR2## where the wavy line has the meaning given above and Me designates an alkali metal, preferably lithium or magnesium, by treating said enolate with a bifunctional nitrogen derivative of formula ##STR3## where the asterisk identifies a center of chirality;index n stands for zero or 1;each of symbols R.sup.0 and R.sup.1 defines a linear or branched alkyl or aralkyl radical, or one of them represents a hydrogen atom and the other an alkyl radical as defined above;each of symbols R.sup.2 and R.sup.3 represents a linear to branched alkyl radical, or one of them represents a hydrogen atom and the other an alkyl such as defined above; andZ designates an OH group or a divalent radical of formula HN--C(O), the nitrogen atom of which is bound to the carbon atom at position 3 and the carbonyl group is bound to the nitrogen atom at position 1;and wherein the nitrogen atom at position 1 can be optionally bound to a benzylic group of a polystyrenic resin;hydrolyzing the reaction mixture and isomerizing it by means of an isomerization agent.Cycloaliphatic ketones (I) are also prepared starting from an organomagnesium compound of formula ##STR4## where the wavy line has the above given meaning and X designates a halogen atom, by treating said compound with one equivalent of a lithium alkoxide.

    Isomer-directed process for producing asymmetric ketones using catalytic Claisen rearrangement of allylic ethers, intermediates, and uses of products and intermediates of process in perfumery
    6.
    发明授权
    Isomer-directed process for producing asymmetric ketones using catalytic Claisen rearrangement of allylic ethers, intermediates, and uses of products and intermediates of process in perfumery 失效
    使用烯丙基醚的催化Claisen重排，中间体以及香料中产品和方法中间体的用途来生产不对称酮的异构体定向方法

    公开(公告)号：US4933320A

    公开(公告)日：1990-06-12

    申请号：US863983

    申请日：1986-05-16

    申请人： Mark A. Sprecker ,  Robert P. Belko ,  William L. Schreiber ,  Michael Licciardello

    发明人： Mark A. Sprecker ,  Robert P. Belko ,  William L. Schreiber ,  Michael Licciardello

    IPC分类号： C07C43/303 ,  C07C43/305 ,  C07C45/51 ,  C07C49/203 ,  C07C49/217 ,  C07C49/557 ,  C11B9/00

    CPC分类号： C11B9/0034 ,  C07C403/10 ,  C07C403/16 ,  C07C43/303 ,  C07C43/305 ,  C07C45/515 ,  C07C49/203 ,  C07C49/217 ,  C07C49/557 ,  C07C2101/14 ,  C07C2101/16

    摘要： Described is an isomer-directed process for producing asymmetric ketones defined according to the generic structure: ##STR1## wherein one of Z.sub.1 or Z.sub.2 is the moiety: ##STR2## and the other of Z.sub.1 or Z.sub.2 is hydrogen; wherein R.sub.11 and R.sub.21 represent hydrogen or the same or different alkyl or alkenyl with the proviso that R.sub.11 and R.sub.21 are not both hydrogen or wherein R.sub.11 and R.sub.21 taken together:(i) complete a cycloalkyl, cycloalkenyl, bicycloalkyl, mono or polyalkyl cycloalkyl or mono or polyalkyl cycloalkenyl ring, or(ii) represent alkylidene, cycloalkenyl alkylidene, aralkylidene, mono or polyalkyl cycloalkenyl alkylidene or mono or polyalkyl aralkylidene;and wherein R.sub.6, R.sub.7 and R.sub.8 are the same or different and each represents hydrogen or methyl, using a catalytic Claisen rearrangement of allylic ethers previously formed by reacting substituted or unsubstituted allylic alcohols defined according to the structure: ##STR3## with dialkyl ketals defined according to the structure: ##STR4## wherein R.sub.4 and R.sub.5 represent the same or different C.sub.1 -C.sub.4 alkyl.Also described are compounds and processes for using same in perfumery defined according the structures: ##STR5## Also described are certain diallylic ethers defined according to the generic structure: ##STR6##

    摘要翻译： 描述了根据通用结构定义的不对称酮的异构体定向方法：其中Z1或Z2之一为部分：Z1和Z2中的另一个为氢; 其中R11和R21表示氢或相同或不同的烷基或烯基，条件是R11和R21不同时为氢或其中R11和R21一起组合：（i）完成环烷基，环烯基，双环烷基，单或多烷基环烷基或单 或聚烷基环烯基环，或（ii）代表亚烷基，环烯基亚烷基，亚烷叉基，单或多烷基环烯基亚烷基或单或多烷基亚烷基; 并且其中R 6，R 7和R 8相同或不同，并且各自表示氢或甲基，使用以前通过使根据以下结构定义的取代或未取代的烯丙基醇反应形成的烯丙基醚的催化Claisen重排：＆lt; IMAGE＆gt; 结构：其中R 4和R 5表示相同或不同的C 1 -C 4烷基。 还描述了根据以下结构定义的香水中使用它们的化合物和方法： + TR 是根据通用结构定义的某些二烯丙基醚：

    Process for the preparation of cycloaliphatic ketones
    7.
    发明授权
    Process for the preparation of cycloaliphatic ketones 失效
    制备脂环族酮的方法

    公开(公告)号：US4900870A

    公开(公告)日：1990-02-13

    申请号：US91640

    申请日：1987-09-01

    申请人： Charles Fehr ,  Jose Galindo

    发明人： Charles Fehr ,  Jose Galindo

    IPC分类号： C11B9/00 ,  A61K8/00 ,  A61K8/35 ,  A61Q13/00 ,  C07C45/00 ,  C07C45/42 ,  C07C45/45 ,  C07C45/51 ,  C07C49/557 ,  C07C67/00 ,  C07C403/00 ,  C07C403/14 ,  C07C403/16

    CPC分类号： C07C403/16 ,  C07C45/004 ,  C07C45/45 ,  C07C45/511 ,  C07C49/557 ,  C07C2101/14

    摘要： Process for the preparation of cycloaliphatic ketones of formula ##STR1## wherein index m designates integer 0, 1 or 2, n stands for 0 or 1 and the dotted lines represent an optional supplemental bond, which process consists in the deprotonation of an ester of formula ##STR2## having either an isolated double bond in position 1 or 2 (exocyclic), or two conjugated double bonds in position 1 and 3 or 2 (exocyclic) and 3 as indicated by the dotted lines, and wherein symbol R' represents a linear or branched alkyl radical, preferably a C.sub.1 -C.sub.6 alkyl radical, or a substituted or unsubstituted phenyl, and Y designates an oxygen or a sulphur atom, the deprotonation being followed by the addition of an organo-metallic compound of formula ##STR3## wherein m and n have the meaning defined above and Z represents a MgX radical or an alkali metal, preferably lithium, X defining a halogen and the dotted lines an optional supplemental bond, and finally a hydrolysis.

    摘要翻译： 制备式（II）的脂环族酮的方法，其中指数m表示整数0,1或2，n表示0或1，虚线表示任选的补充键，该方法包括将 具有位置1或2（环外）的分离双键或位置1和3或2（环外）的2个共轭双键和如虚线所示3的式（III）的酯，其中 符号R'表示直链或支链烷基，优选C1-C6烷基或取代或未取代的苯基，Y表示氧或硫原子，去质子化后，加入有机金属化合物 （V）其中m和n具​​有上述定义，Z表示MgX基团或碱金属，优选锂，X限定卤素，虚线是任选的补充键，最后是水解。