Invention Application
- Patent Title: ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST
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Application No.: US16166893Application Date: 2018-10-22
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Publication No.: US20190055182A1Publication Date: 2019-02-21
- Inventor: Brian M. Stoltz , Alexander N. Marziale , Robert A. Craig , Douglas Duquette , Kelly E. Kim , Marc Liniger , Yoshitaka Numajiri
- Applicant: California Institute of Technology
- Main IPC: C07C45/65
- IPC: C07C45/65 ; C07D211/94 ; C07D223/10 ; B01J31/04 ; C07D317/72 ; C07C49/647 ; C07C49/683
Abstract:
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
Information query
