Described herein are methods of using biomarker levels to detect proteins in a biological sample obtained from a patient with ovarian cancer, calculate a quantitative score for a patient with ovarian cancer, and predict a likelihood of a clinical outcome in a patient with ovarian cancer. The methods involve determining a level of at least three proteins in the biological sample obtained from the patient wherein the at least three proteins are selected from ANG-2, HE4, PROSTASIN, EGFR and IL-8, calculating a quantitative score for the patient by weighting the level of the at least three proteins by their contribution to a clinical outcome, and/or predicting a likelihood of a clinical outcome for the patient based on the quantitative score. Also provided are sets of reagents and test kits to the levels of the biomarkers described herein.