Invention Application
- Patent Title: SIRT4 LIPOAMIDASE ACTIVITY AND USES THEREOF
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Application No.: US15106932Application Date: 2015-01-15
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Publication No.: US20190094225A1Publication Date: 2019-03-28
- Inventor: Thomas Shenk , Todd M. Greco , IIeana M. Cristea , Rommel A. Mathias , Adam Oberstein
- Applicant: The Trustees of Princeton University
- International Application: PCT/US15/11585 WO 20150115
- Main IPC: G01N33/573
- IPC: G01N33/573
Abstract:
The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
Public/Granted literature
- US10788492B2 SIRT4 lipoamidase activity and uses thereof Public/Granted day:2020-09-29
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