This invention relates to novel non-isocyanate siloxane-modified glycidol carbamate (GC) resins and coating compositions containing them. The non-isocyanate siloxane modified GC resins of the invention comprise the reaction product of at least one organic polyisocyanate, glycidol, and at least one bis(hydroxyl alkyl)-terminated polydimethylsiloxane. The coating compositions of the invention comprise at least one non-isocyanate siloxane modified GC resin of the invention and at least one curing agent. The invention also relates to methods of making the resins of the invention and coatings containing them. The invention also relates to a fouling-release (FR) coating system comprising the coating compositions of the invention and methods of applying said FR coating systems to substrates. The invention also relates to articles of manufacture comprising a coating composition of the invention and a method of making such articles.