- 专利标题: TISSUE-ADHESIVE POROUS HAEMOSTATIC PRODUCT
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申请号: US16226374申请日: 2018-12-19
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公开(公告)号: US20190125922A1公开(公告)日: 2019-05-02
- 发明人: Johannes Caspar Mathias Elizabeth BENDER , Marcel Alexander BOERMAN
- 申请人: GATT Technologies B.V.
- 申请人地址: NL Nijmegen
- 专利权人: GATT Technologies B.V.
- 当前专利权人: GATT Technologies B.V.
- 当前专利权人地址: NL Nijmegen
- 优先权: EP14187781.1 20141006
- 主分类号: A61L15/26
- IPC分类号: A61L15/26 ; A61L15/58 ; A61L15/32 ; A61L15/42
摘要:
A process of preparing an adhesive haemostatic product is provided. The process comprises: (a) coating a porous solid substrate with a coating liquid that comprises an electrophilically activated polyoxazoline (EL-POX) and a solvent to produce a coated substrate; and (b) removing the solvent from the coated substrate. The EL-POX comprises at least 2 reactive electrophilic groups. The process enables the application of an EL-POX coating that leaves the pore structure of the substrate largely intact so that the ability of the porous substrate to absorb body fluids, such as blood, remains essentially unaffected. The EL-POX coated haemostatic product obtained by the present process has excellent adhesive properties due to the presence of electrophilic reactive groups that are capable of reacting with e.g. amine groups that are naturally present in tissue, under the formation of covalent bonds.
公开/授权文献
- US10751441B2 Tissue-adhesive porous haemostatic product 公开/授权日:2020-08-25
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