- 专利标题: BISPECIFIC ANTIBODIES TARGETING EGFR AND HER2
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申请号: US16096698申请日: 2017-04-28
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公开(公告)号: US20190153104A1公开(公告)日: 2019-05-23
- 发明人: EUGENE ZHUKOVSKY , OLIVIER LEGER , PIERRE-EMMANUEL GERARD , ANDRE PELEGRIN , CHRISTEL LARBOURET
- 申请人: BIOMUNEX PHARMACEUTICALS , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE MONTPELLIER , INSTITUT REGIONAL DU CANCER DE MONTPELLIER (ICM)
- 优先权: EP16305496.8 20160428
- 国际申请: PCT/EP2017/060280 WO 20170428
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K16/46 ; A61P35/00
摘要:
The present disclosure relates to bispecific antibodies targeting EGFR and HER2, and methods for the production of these antibodies. The bispecific antibodies consist of one complete antibody on which two VH-VL chains are attached via a linker to each NH terminal region of both VH chains of the antibody. The bispecific antibodies constructed use the amino acid sequences of the heavy chain (VH) and the light chain (VL) variable regions of two monoclonal antibodies targeting EGFR and HER2, namely cetuximab and trastuzumab, respectively.
公开/授权文献
- US12054550B2 Bispecific antibodies targeting EGFR and HER2 公开/授权日:2024-08-06
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