公开(公告)号：US20190153104A1

公开(公告)日：2019-05-23

申请号：US16096698

申请日：2017-04-28

申请人： BIOMUNEX PHARMACEUTICALS ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE MONTPELLIER ,  INSTITUT REGIONAL DU CANCER DE MONTPELLIER (ICM)

发明人： EUGENE ZHUKOVSKY ,  OLIVIER LEGER ,  PIERRE-EMMANUEL GERARD ,  ANDRE PELEGRIN ,  CHRISTEL LARBOURET

IPC分类号： C07K16/28 ,  C07K16/46 ,  A61P35/00

摘要： The present disclosure relates to bispecific antibodies targeting EGFR and HER2, and methods for the production of these antibodies. The bispecific antibodies consist of one complete antibody on which two VH-VL chains are attached via a linker to each NH terminal region of both VH chains of the antibody. The bispecific antibodies constructed use the amino acid sequences of the heavy chain (VH) and the light chain (VL) variable regions of two monoclonal antibodies targeting EGFR and HER2, namely cetuximab and trastuzumab, respectively.

公开(公告)号：US20230322952A1

公开(公告)日：2023-10-12

申请号：US17791549

申请日：2021-01-08

申请人： BIOMUNEX PHARMACEUTICALS ,  INSTITUT CURIE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人： OLIVIER LANTZ ,  SEBASTIAN AMIGORENA ,  MICHAEL SAITAKIS ,  MAUDE GUILLOT-DELOST ,  EUGENE ZHUKOVSKY ,  PIERRE-EMMANUEL GERARD ,  MUSTAPHA FAROUDI

IPC分类号： C07K16/46 ,  A61P35/00

CPC分类号： C07K16/468 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/522 ,  C07K2317/565

摘要： The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a Vα7.2 T cell receptor (TCR) and at least one domain that specifically binds a tumor associated antigen (TAA).