- 专利标题: LIVE ATTENUATED ZIKA VIRUS VACCINE
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申请号: US16083652申请日: 2017-03-11
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公开(公告)号: US20190194260A1公开(公告)日: 2019-06-27
- 发明人: Stephen S. Whitehead , Sara E. Woodson , Anna P. Durbin , Alexander G. Pletnev , Konstantin A. Tsetsarkin
- 申请人: The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Johns Hopkins University
- 申请人地址: US MD Bethesda US MD Baltimore
- 专利权人: The United States of America, as represented by the Secretary, Dept. of Health and Human Services,The Johns Hopkins University
- 当前专利权人: The United States of America, as represented by the Secretary, Dept. of Health and Human Services,The Johns Hopkins University
- 当前专利权人地址: US MD Bethesda US MD Baltimore
- 国际申请: PCT/US17/21989 WO 20170311
- 主分类号: C07K14/005
- IPC分类号: C07K14/005 ; A61K39/12
摘要:
The present disclosure relates to attenuated Zika viruses and vaccines, attenuated chimeric Zika viruses and vaccines, and to multivalent immunogenic compositions comprising Zika vaccines and vaccines to other flaviviruses. The chimeric Zika viruses includes a first nucleotide sequence encoding at least one structural protein from a Zika virus (ZIKV), a second nucleotide sequence encoding at least one nonstructural protein from a first flavivirus, and a third nucleotide sequence of a 3′ untranslated region from a second flavivirus. The multivalent immunogenic compositions comprise an attenuated ZIKV vaccine or an attenuated chimeric ZIKV vaccine (or their combination) together with one or more of a first attenuated virus that is immunogenic against dengue serotype 1, a second attenuated virus that is immunogenic against dengue serotype 2, a third attenuated virus that is immunogenic against dengue serotype 3, and a fourth attenuated virus that is immunogenic against dengue serotype 4. The present disclosure further relates to methods of inducing immune responses, as well as preventing or treating ZIKV infections, and in certain embodiments, the combined prevention or treatment of ZIKV and another flavivirus, e.g., dengue virus.