A multi-outlet-inlet laminated liquid-cooling heat dissipation structure includes a top plate, a bottom plate mated with the top plate, a substrate disposed between the top plate and the bottom plate and multiple communication passages. The substrate has an upper face, a lower face and at least one communication unit. The top plate and the upper face together define an upper liquid chamber. The bottom plate and the lower face together define a lower liquid chamber. The at least one communication unit passes through the substrate between the upper and lower faces to communicate with the upper and lower liquid chambers for a working fluid to flow through. Each communication passage has a communication opening in communication with the upper and lower liquid chambers as an inlet or an outlet of the working fluid.