发明申请
- 专利标题: POLY(CYCLIC IMINO ETHER)S
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申请号: US16312219申请日: 2017-07-03
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公开(公告)号: US20190231889A1公开(公告)日: 2019-08-01
- 发明人: Richard HOOGENBOOM , Bart VERBRAEKEN
- 申请人: UNIVERSITEIT GENT
- 申请人地址: BE Gent (Zwijnaarde)
- 专利权人: UNIVERSITEIT GENT
- 当前专利权人: UNIVERSITEIT GENT
- 当前专利权人地址: BE Gent (Zwijnaarde)
- 优先权: EP16177411.2 20160701
- 国际申请: PCT/EP2017/066489 WO 20170703
- 主分类号: A61K47/59
- IPC分类号: A61K47/59 ; A61K47/69 ; A61K48/00 ; C08G73/02
摘要:
The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]m-[Oz]n-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R1)CHRaCHRa; each R1 independently represents H or C(O)R11; and R11 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R2)CHRaCHRaCHRa; each R2 independently represents C(O)R21 or H; and R21 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Ra independently represents H, linear or branched C1-3 alkyl; m≥5; n≥5; m+n≥20; 3:97≤m:n≤97:3. The statistical copolymers of the present invention exhibit useful properties that can be exploited in the medical field, especially in polymer micelles for drug delivery and polyplexes for DNA delivery.