- 专利标题： Pyrimidone Compounds Used as Lp-PLA2 Inhibitors and Pharmaceutical Compositions Thereof
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申请号： US16299636申请日： 2019-03-12
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公开(公告)号： US20190248751A1公开(公告)日： 2019-08-15
- 发明人: Jianhua Shen , Yiping Wang , Xinde Chen , Wenwei Xu , Kai Wang
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 优先权： CN201410855183.5 20141226
- 主分类号： C07D239/54
- IPC分类号： C07D239/54 ; C07D239/56 ; C07D409/04 ; C07D403/06 ; C07D403/04 ; C07D401/12 ; A61K31/513 ; C07D413/04 ; C07D239/545 ; C07D239/52 ; C07D239/48 ; A61K31/541 ; C07D401/04
摘要：
The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.
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