公开(公告)号：US20180009766A1

公开(公告)日：2018-01-11

申请号：US15540025

申请日：2015-12-28

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Jianhua Shen ,  Yiping Wang ,  Xinde Chen ,  Wenwei Xu ,  Kai Wang

IPC分类号： C07D239/54 ,  C07D409/04 ,  C07D403/06 ,  C07D401/12 ,  C07D239/48 ,  C07D401/04 ,  C07D239/56 ,  C07D239/545 ,  C07D413/04 ,  C07D403/04

CPC分类号： C07D239/54 ,  A61K31/513 ,  A61K31/541 ,  C07D239/48 ,  C07D239/52 ,  C07D239/545 ,  C07D239/56 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D409/04 ,  C07D413/04

摘要： The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.

公开(公告)号：US20190248751A1

公开(公告)日：2019-08-15

申请号：US16299636

申请日：2019-03-12

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Jianhua Shen ,  Yiping Wang ,  Xinde Chen ,  Wenwei Xu ,  Kai Wang

IPC分类号： C07D239/54 ,  C07D239/56 ,  C07D409/04 ,  C07D403/06 ,  C07D403/04 ,  C07D401/12 ,  A61K31/513 ,  C07D413/04 ,  C07D239/545 ,  C07D239/52 ,  C07D239/48 ,  A61K31/541 ,  C07D401/04

摘要： The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.

公开(公告)号：US10787422B2

公开(公告)日：2020-09-29

申请号：US16299636

申请日：2019-03-12

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Jianhua Shen ,  Yiping Wang ,  Xinde Chen ,  Wenwei Xu ,  Kai Wang

IPC分类号： A61K31/513 ,  C07D239/54 ,  A61K31/541 ,  C07D401/04 ,  C07D403/04 ,  C07D239/48 ,  C07D409/04 ,  C07D239/52 ,  C07D239/545 ,  C07D239/56 ,  C07D401/12 ,  C07D403/06 ,  C07D413/04

摘要： The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.

公开(公告)号：US10280146B2

公开(公告)日：2019-05-07

申请号：US15540025

申请日：2015-12-28

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Jianhua Shen ,  Yiping Wang ,  Xinde Chen ,  Wenwei Xu ,  Kai Wang

IPC分类号： A61K31/541 ,  C07D239/54 ,  A61K31/513 ,  C07D401/04 ,  C07D403/04 ,  C07D239/48 ,  C07D409/04 ,  C07D239/52 ,  C07D239/545 ,  C07D239/56 ,  C07D401/12 ,  C07D403/06 ,  C07D413/04

摘要： The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.