Invention Application
- Patent Title: PHOSPHOPEPTIDE-ENCODING OLIGONUCLEOTIDE LIBRARIES AND METHODS FOR DETECTING PHOSPHORYLATION-DEPENDENT MOLECULAR INTERACTIONS
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Application No.: US16278610Application Date: 2019-02-18
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Publication No.: US20190256843A1Publication Date: 2019-08-22
- Inventor: Jesse Rinehart , Karl Barber , Farren Isaacs , Jeffrey R. Sampson
- Applicant: Yale University , Agilent Technologies, Inc.
- Main IPC: C12N15/10
- IPC: C12N15/10
Abstract:
The present invention relates to libraries of phosphopeptide-encoding oligonucleotides and methods of preparing such libraries. The present invention also relates to methods of detecting, visualizing, or screening for phosphorylation-dependent protein-protein interactions using recombinant phosphopeptides and/or phosphopeptide-encoding oligonucleotides. The present invention also relates to sets or kits of oligonucleotides having regions that encode phosphopeptides.
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