- 专利标题： ISOLATED POLYPEPTIDE OF THE TOXIN A AND TOXIN B PROTEINS OF C. DIFFICILE AND USES THEREOF
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申请号： US16295031申请日： 2019-03-07
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公开(公告)号： US20190290747A1公开(公告)日： 2019-09-26
- 发明人: Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
- 申请人： Valneva Austria GmbH
- 申请人地址： AT Vienna
- 专利权人： Valneva Austria GmbH
- 当前专利权人： Valneva Austria GmbH
- 当前专利权人地址： AT Vienna
- 主分类号： A61K39/08
- IPC分类号： A61K39/08 ; C07K16/12 ; C07K14/33
摘要：
This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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