公开(公告)号：US20250018023A1

公开(公告)日：2025-01-16

申请号：US18799291

申请日：2024-08-09

Applicant: Valneva Austria GMBH

Inventor： Jana Barbero Calzado ,  Mario Nebenführ ,  Robert Schlegl ,  Michael Weber ,  Jürgen Heindl-Wruss

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/39 ,  A61P31/14 ,  C07K14/18 ,  C12N7/00 ,  C12N7/02 ,  C12N7/06

Abstract: Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

公开(公告)号：US20240293531A1

公开(公告)日：2024-09-05

申请号：US17913638

申请日：2021-04-06

Applicant: Valneva Austria GmbH

Inventor： Andreas Meinke ,  Michael Möhlen ,  Robert Schlegl ,  Jürgen Heindl-Wruss

IPC: A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/575 ,  C12N2770/20034 ,  C12N2770/20063

Abstract: Described herein are SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

公开(公告)号：US11684669B2

公开(公告)日：2023-06-27

申请号：US17471904

申请日：2021-09-10

Applicant: Valneva Austria GmbH ,  Dynavax Technologies Corporation

Inventor： Andreas Meinke ,  Michael Möhlen ,  Christoph Reinisch ,  Robert Schlegl ,  Christian Taucher ,  John Campbell ,  David Novack ,  Robert S. Janssen ,  Jürgen Heindl-Wruss

IPC: C12N7/00 ,  A61K39/215 ,  A61K39/00

CPC classification number: A61K39/215 ,  A61K2039/545 ,  A61K2039/55561

Abstract: Described herein are CpG-adjuvanted SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

公开(公告)号：US20200017555A9

公开(公告)日：2020-01-16

申请号：US16063007

申请日：2016-12-23

Applicant: VALNEVA AUSTRIA GMBH

Inventor： Jana BARBERO CALZADO ,  Mario NEBENFÜHR ,  Robert SCHLGEL ,  Michael WEBER ,  Jürgen HEINDL-WRUSS

IPC: C07K14/18 ,  C12N7/06

Abstract: Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

公开(公告)号：US20190290747A1

公开(公告)日：2019-09-26

申请号：US16295031

申请日：2019-03-07

Applicant: Valneva Austria GmbH

Inventor： Larry R. Ellingsworth ,  David Flyer ,  Jing-Hui Tian ,  Steven R. Fuhrmann ,  Stefanie Kluepfel-Stahl ,  Gregory M. Glenn ,  Kerstin Westritschnig

IPC: A61K39/08 ,  C07K16/12 ,  C07K14/33

Abstract: This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.

公开(公告)号：US09975927B2

公开(公告)日：2018-05-22

申请号：US15110151

申请日：2015-01-09

Applicant: Valneva Austria GmbH

Inventor： Urban Lundberg ,  Wolfgang Schüler

IPC: C07K14/20 ,  A61K39/02 ,  C07K16/12 ,  A61K39/39 ,  A61K39/00

CPC classification number: C07K14/20 ,  A61K39/0225 ,  A61K39/39 ,  A61K2039/55516 ,  A61K2039/70 ,  C07K16/1207 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2319/00 ,  C07K2319/21 ,  Y02A50/401

Abstract: The present invention relates to compositions and methods for the prevention and treatment of Borrelia infection. Particularly, the present invention relates to a polypeptide comprising a hybrid C-terminal fragment of an outer surface protein A (OspA), a nucleic acid coding the same, an antibody specifically binding the same, a pharmaceutical composition (particularly for use as a medicament or in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid and/or the antibody, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.

公开(公告)号：US09913898B2

公开(公告)日：2018-03-13

申请号：US15223027

申请日：2016-07-29

Applicant: Valneva Austria GmbH

Inventor： Robert Schlegl ,  Michael Möhlen ,  Jürgen Wruss ,  Michael Weber

IPC: A61K39/00 ,  A61K39/39 ,  C07D487/04 ,  C09K13/00 ,  A61K38/43 ,  A61K38/16 ,  A61K39/12 ,  C12N7/00 ,  A61K39/104

CPC classification number: A61K39/39 ,  A61K38/162 ,  A61K38/164 ,  A61K39/104 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/24134 ,  Y02A50/39

Abstract: The invention relates to means and methods for preparing aqueous composition comprising aluminum and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminum content. The invention further relates to aqueous compositions comprising a protein and an aluminum-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.

公开(公告)号：US20160324959A1

公开(公告)日：2016-11-10

申请号：US15223027

申请日：2016-07-29

Applicant: Valneva Austria GmbH

Inventor： ROBERT SCHLEGL ,  Michael Möhlen ,  Jürgen Wruss ,  Michael Weber

IPC: A61K39/39 ,  C12N7/00 ,  A61K39/104 ,  A61K39/12

CPC classification number: A61K39/39 ,  A61K38/162 ,  A61K38/164 ,  A61K39/104 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/24134 ,  Y02A50/39

Abstract: The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.

公开(公告)号：US20150216967A1

公开(公告)日：2015-08-06

申请号：US14258119

申请日：2014-04-22

Applicant: Valneva Austria GmbH

Inventor： Benjamin Wizel ,  Karin Riedl ,  Karen Lingnau ,  Ursula Schlosser ,  Jürgen Wruss ,  Robert Schlegl ,  Michael Weber ,  Christoph Reinisch ,  Ljubomir Paucz ,  Christoph Klade ,  Jee Loon Look ,  Christian Ruiz ,  Robert Seid

IPC: A61K39/39 ,  C12N7/00 ,  A61K39/09 ,  A61K39/145 ,  A61K9/14 ,  A61K39/118

CPC classification number: A61K39/39 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/092 ,  A61K39/118 ,  A61K39/12 ,  A61K39/145 ,  A61K39/40 ,  A61K39/42 ,  A61K48/00 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16234 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396 ,  Y02A50/401 ,  Y02A50/412 ,  Y02A50/47

Abstract: The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm.

Abstract translation: 本发明公开了液体形式的药物组合物，其包含具有氨基酸序列KLKL5KLK的肽和具有核酸序列（dIdC）13的寡脱氧核苷酸的肽，并且其中肽和寡脱氧核苷酸作为无菌可过滤纳米粒子存在于组合物中，由此形成 悬浮液，其特征在于固体颗粒的平均粒径小于1μm。

公开(公告)号：US12102673B2

公开(公告)日：2024-10-01

申请号：US18334497

申请日：2023-06-14

Applicant: Valneva Austria GmbH

Inventor： Jana Barbero Calzado ,  Mario Nebenführ ,  Robert Schlegl ,  Michael Weber ,  Jürgen Heindl-Wruss

IPC: A61K39/12 ,  A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61P31/14 ,  C07K14/18 ,  C12N7/00 ,  C12N7/02 ,  C12N7/06

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61P31/14 ,  C07K14/18 ,  C07K14/1825 ,  C12N7/00 ,  C12N7/02 ,  C12N7/06 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5258 ,  A61K2039/55505 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  Y02A50/30

Abstract: Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.